Endocrine Abstracts

Objective: To determine the Predictors of growth response to GH treatment in a group of isolated idiopathic GH (GH).Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year up to 6 years. Multiple linear regressions were done to identify predictors of growth response to rhGH in the first 4 years of treatment.Results: In the first year, three ...

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of β cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 d...

Background: Polycystic ovarian syndrome (PCO) is the most common endocrinopathy in adult women, and is emerging as a common cause of menstrual disturbance in the adolescent population. Insulin resistance, which is considered one of its underlying causes, has increased substantially in the past decade, putting more adolescent girls at risk for PCOS and its complications. Anti – Mullerian hormone (AMH) is secreted by the granulose...

Multiple factors contribute to the etiology of Graves disease(GD), including genetic and environmental factors.vitamin D is well known in calcium metabolism and has also been shown to be a modulator in innate and adaptive immunity. There is a well-established link between vitamin D deficiency and various autoimmune diseases. The prevalence of vitamin D deficiency was reported to be common in patients with GD. Whether vitamin D deficiency has a causal relationship with GD remai...

Type 1 diabetes mellitus (DM) is a multi system disease with both biochemical and anatomic/structural consequences. A number of components of the metabolic syndrome may be observed in patients with type 1 diabetes. It was suggested that treating obese adolescents with insulin resistance using metformin is an option for patients without response to traditional lifestyle change. It was reported that fetuin-A could inhibit insulin receptor tyrosine kinase activity and induced a l...

There is evidence that vitamin D has a variety of effects on immune system function, which may enhance innate immunity and inhibit the development of autoimmunity. It suppresses T-cell proliferation, and inhibits secretion of pro-inflammatory Th1- and Th2-related Cytokines. In Graves’ ophthalmopathy (GO), a diffuse infiltration of lymphocytes is seen in the orbital adipose tissues and extracellular muscles. Th1 and 2 appear to play a role GO.Aim: To...

Introduction: Congenital hyperinsulinism (CHI), is the most frequent cause of persistent hypoglycemia in infancy. Mutations in the ABCC8 gene are responsible for 40–50% of CHI cases. Its management can be extremely complicated. The main goal of the treatment is to maintain normoglycemia, since hypoglycemia during infancy can have severe neurological consequences. Herein, we report 8 year follow up of twin patients who were diagnosed with CHI at neonatal period due to SUR1...

Objective: To study the growth response to GH treatment in GH deficient patients. Also to report the possible side effects emerging during treatment with GH.Patients and methods: 477 GH deficient (GHD) children were included in the study. All patients received biosynthetic GH therapy at a dose of 20 IU/m2 per week. Patients were followed up for a minimum of 1 year and up to 6 years as anthropometric assessment was performed every 3 months, whi...

Aim: Basal energy expenditure (BEE), also called basal metabolic rate, increases in cancer patients and is thought to contribute to the weight loss observed in cancer cachexia. Cancer type, pathological stage and duration of disease influence BEE. The aim of this study was to evaluate BEE and body composition in breast cancer patients.Methods: Forty-three women with breast cancer whose received adjuvant chemotherapy and 80 healthy age and body mass index...

Purpose: Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. We aim to investigate the relation between the upper abdominal obesity and breast cancer, by using ultrasonography (USG).Material and methods: The study population consisted of 44 women in control group and 17 breast cancer patient in study group. In the whole study population fat tissue was measured with high resolution B-mode...